Mathematical modeling and experimental validation of continuous slug-flow tubular crystallization with ultrasonication-induced nucleation and spatially varying temperature

• Slug-flow crystallization employs spatially varying temperature and ultrasonication. Smaller crystals are obtained by including a section with rising temperature. A population balance model is constructed for the continuous tubular crystallizer. First to incorporate ultrasonication dissolution. Model agrees data many combinations of ultrasonic power Continuous slug-flow has been explored several research groups in academia industry as way produce while having low capital equipment costs. In this type, slugs slurry gas consecutively travel through tube, high degree mixing uniformity within each slug. This article presents an experimental system that spatial profile directed non-contact induce primary nucleation enable generation wide variety crystal size distributions. The distributions compared collected from full-factorial design (27 experiments total) predictions includes effects on nucleation. first incorporates dissolution distribution. reasonably consistent model, 20% prediction error, all which monotonically decreasing at moderate supersaturation. Potential causes weaker agreement other discussed.